Computer users are often the last line of defense in computer security. However, with repeated exposures to system messages and computer security warnings, neural and behavioral responses show evidence of habituation. Habituation has been demonstrated at a neural level as repetition suppression where responses are attenuated with subsequent repetitions. In the brain, repetition suppression to visual stimuli has been demonstrated in multiple cortical areas, including the occipital lobe and medial temporal lobe. Prior research into the repetition suppression effect has generally (...) focused on a single repetition and has not examined the pattern of signal suppression with repeated exposures. We used complex, everyday stimuli, in the form of images of computer programs or security warning messages, to examine the repetition suppression effect across repeated exposures. The use of computer warnings as stimuli also allowed us to examine the activation of learned fearful stimuli. We observed widespread linear decreases in activation with repeated exposures, suggesting that repetition suppression continues after the first repetition. Further, we found greater activation for warning messages compared to neutral images in the anterior insula, pre-supplemental motor area, and inferior frontal gyrus, suggesting differential processing of security warning messages. However, the repetition suppression effect was similar in these regions for both warning messages and neutral images. Additionally, we observed an increase of activation in the default mode network with repeated exposures, suggestive of increased mind wandering with continuing habituation. (shrink)

One of the theses defended by Aristotle in Nicomachean Ethics books VII and X is that pleasure is good or is one of the good things : and Aristotle thinks that it follows from this that the best thing is a pleasure, or is pleasure in a certain way. Among his arguments for the latter we find the following:The fact that all things, both brutes and men, pursue pleasure is an indication that the best thing is in a certain way (...) that. (shrink)

Alzheimer's disease is characterized by amyloid-beta peptide -loaded plaques in the brain. Abeta is a cleavage fragment of amyloid-beta protein precursor and over production of APP may lead to amyloidogenesis. The regulatory region of the APP gene contains consensus sites recognized by the transcription factor, specificity protein 1 , which has been shown to be required for the regulation of APP and Abeta. To understand the role of SP1 in APP biogenesis, herein we have characterized the relative distribution and localization (...) of SP1, APP, and Abeta in various brain regions of rodent and primate models using immunohistochemistry. We observed that overall distribution and cellular localization of SP1, APP, and Abeta are similar and neuronal in origin. Their distribution is abundant in various layers of neocortex, but restricted to the Purkinje cell layer of the cerebellum, and the pyramidal cell layer of hippocampus. These findings suggest that overproduction of Abeta in vivo may be associated with transcriptional pathways involving SP1 and the APP gene. (shrink)

We report here on an ongoing study of a self-defining community of physicists whose work spans an interestingly diverse set of subjects, typically in the borderland between macroscopic and microscopic description and between quantum and classical domains. Its methods are typically semi-classical. It is this borderland—of people, subject, and methods—in which we are primarily interested and which we will attempt to characterise. For concreteness, we will focus on the subset of ‘quantum chaos’ and more particularly on the work that the (...) physicists Eric Heller and Steven Tomsovic have called ‘postmodern quantum mechanics’, using their characterisation to ground a somewhat more expansive interpretation. (shrink)

This article is an invited comment on the article by George Mandler in the same issue. It is suggested that the latter contains a series of myths that are popular among psychologists. These are that psychology was fragmented into “schools” in the 1920s and 30s and that this led several writers to declare that it was in a state of crisis. It is said to have overcome this crisis by becoming more eclectic and incorporating the best aspects of the various (...) schools. The author suggests that the reality is very different; there is no evidence to suggest that modern psychology has incorporated different aspects of the various schools. It is just as fragmented as it was in the early part of the 20th century, and the crisis literature has continued to the present day. It is suggested that the myths serve the quasi-religious function of keeping faith in the progress of psychology toward “mature science” alive. 2012 APA, all rights reserved). (shrink)

Is the societal-level of analysis sufficient today to understand the values of those in the global workforce? Or are individual-level analyses more appropriate for assessing the influence of values on ethical behaviors across country workforces? Using multi-level analyses for a 48-society sample, we test the utility of both the societal-level and individual-level dimensions of collectivism and individualism values for predicting ethical behaviors of business professionals. Our values-based behavioral analysis indicates that values at the individual-level make a more significant contribution to (...) explaining variance in ethical behaviors than do values at the societal-level. Implicitly, our findings question the soundness of using societal-level values measures. Implications for international business research are discussed. (shrink)

The sporadic nature of Alzheimer's disease argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead during brain development predetermined the expression and regulation of the amyloid precursor protein and its amyloidogenic beta-amyloid product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ] as well as their transcriptional regulator were elevated in aged (...) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of Abeta staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD. (shrink)

Are corporations morally defensible sorts of entities? How might we go about showing that they are? Thomas Donaldson offers us the most detailed contractarian justification for the moral defensibility of corporations. In this paper I show how we can significantly develop this sort of justification to yield a more compelling contractarian justification, though one that is importantly conditional. The primary points I take up in this paper are these:1. The question Donaldson poses to generate his contract is not quite as (...) simple as may appear. The sort of transformation we need to consider is more complex than the sort Donaldson describes.2. Partly because of considerations that arise in discussing the first point, the contract we are considering is a more conditionalagreement. The terms of the agreement will vary depending on the kind of state we are assuming prevails. The sort of contract we wantto draw up is at least a three-way contract: between society, productive organizations and the state. The sort of agreement we reach will have the following form: society a agrees to allow productive organizations of type b to exist if we assume state c will do various things (d1 to dn), productive organizations will do various things (e1 to en) and members of society will do various things (f1 to fn). Importantly, if state c is not doing d1 to dn, productive organizations may not be morally defensible.3. The terms of the contract that can be derived would benefit from the introduction of some of Rawls’s apparatus.4. When we consider the right questions, with more of the background institutions filled in, and when we include some more social contract apparatus, we get a better contract which fills in for us not only the obligations of business but, importantly, many obligationsfor government as well. (shrink)

In this article we argue that the concept of need is as vital for moral theory as it is for moral life. In II we analyse need and its normativity in public and private moral practice. In III we describe simple cases which exemplify the moral demandingness of needs, and argue that the significance of simple cases for moral theory is obscured by the emphasis in moral philosophy on unusual cases. In IV we argue that moral theories are inadequate if (...) they cannot describe simple needs-meeting cases. We argue that the elimination or reduction of need to other concepts such as value, duty, virtue or care is unsatisfactory, in which case moral theories that make those concepts fundamental will have to be revised. In conclusion, we suggest that if moral theories cannot be revised to accommodate needs, they may have to be replaced with a fully needs-based theory. Correspondence:c1 [email protected] g. brock @auckland.ac.nz. (shrink)

By conceiving of autism and psychosis as diametrically opposite phenotypes of underactive and overactive mentalizing, respectively, Crespi & Badcock (C&B) commit themselves to a continuum view of intercorrelated mentalizing functions. This view fails to acknowledge dissociations between mentalizing functions and that psychotic people show a mixture of both hypo- and hyper-mentalizing.

In lieu of an abstract, here is a brief excerpt of the content:The Causality of Prayer and the Execution of Predestination in Thomas AquinasStephen L. BrockIntroduction: The Question of the Reasonableness of Petitionary PrayerIn a lucid and witty essay published in 1945, C. S. Lewis addressed a common objection to the practice of petitionary prayer.1 This practice is not confined to Christianity, of course, but at least in relation to the Christian conception of the deity, it can seem to make (...) little sense. The problem is simple. If God is all-wise and all-good, what is the point of asking him for things? He is already perfectly aware of our true needs, and he already wants to provide for them. Many of our requests are ignorant and misguided, and the others, it seems, will be at best superfluous. Nevertheless, as Lewis observes, petitionary prayer is part of the whole Christian tradition. Jesus himself practiced it, urged his followers to do so, and taught them how. Lewis wanted to explain that the real purpose of the practice is not to inform God of our needs or to twist his arm. Rather, petitionary prayer functions as a kind of cause, a way of bringing things about. It does so by divine institution and as a kind of share in God's own causality. And so understood, it makes perfect sense. I think Lewis is right about this.Another matter, however, is Lewis's particular way of conceiving the causality of petitionary prayer, especially as to its relation to God's own causality and care for the world. I grant that his conception is quite [End Page 15] straightforward and clear, and that it even has a strong initial plausibility. Indeed, I suspect that it gives voice to the way in which many thoughtful people who pray for things conceive of what they are doing. This is why, even though it is not the main focus of the present essay, I think that it serves as a good way of entering to the topic. But I do hope to show that it contains some serious problems.In what follows, I shall first set out Lewis's answer to the question of the reasonableness of petitionary prayer. Then I shall raise one of the problems that I think it faces. This has to do with another attribute that has traditionally been ascribed to the Christian God; namely, omniscience, the knowledge of all things, including all temporal events, past, present, and future. In the essay on prayer, Lewis does not address this problem. But from things that he says elsewhere about temporal events and how God knows them, I think we can gather how he would have solved it.Rather than evaluating this solution myself, I shall turn next to another twentieth-century British thinker, the philosopher Peter Geach. Although Geach agrees with Lewis in ascribing a causal function to petitionary prayer, Geach's way of understanding temporal events and God's knowledge of them contrasts sharply with Lewis's. In fact, Geach argues—I think persuasively—that a position like Lewis's actually ends up making petitionary prayer unable to function as a cause, and therefore renders it pointless. At the same time, however, Geach's own account of how petitionary prayer fits into God's overall plan has something very important in common with Lewis's. And in my opinion, what they have in common is very problematic.This will bring me to my main theme, which is Thomas Aquinas's view of the matter. Like Lewis and Geach, Thomas does regard petitionary prayer as a divinely instituted way of causing things. On their temporal status, his position is similar to Geach's. But on how prayer and its effects fall under God's providential plan, Thomas differs greatly from both authors. I find his account far more satisfactory. Unfortunately, it is also considerably more complicated and philosophically challenging, and my presentation of it will have to be correspondingly longer.The distinctive features of Thomas's view mostly pertain to the metaphysics of divine transcendence. My main task will be to show how, in his account, the full determinacy of God's eternal plan, including that part of it called... (shrink)